To safeguard its economic and security interests, China has adopted a whole-of-region diplomacy in the Middle East since the end of the Cold war. Through a multitude of regional and international organizations, China has been able to maintain constructive interactions with Middle Eastern countries while deepening its ties with other major powers like the United States, the European Union, Russia, Japan and India. China’s diplomatic efforts have paid off in the Middle East and increased the influence of developing countries as a whole in international politics. Meanwhile, China’s whole-of-region diplomacy is faced with a number of challenges given the complexity of ethnic, religious and security landscapes in the Middle East. China needs more holistic and well-coordinated ways of whole-of-region diplomacy to seek closer relationships with Middle Eastern countries. To this end, it is important for China to consolidate its network of strategic partnerships on the basis of bilateral collaboration and multilateral cooperation, further strengthen its discourse power and agenda-setting capacity, and consider adopting a common but differentiated strategy toward regional countries according to their different national conditions, political systems and paths of socioeconomic development.