Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review.
Abstract
Lipid-polymer hybrid nanoparticles (LPNs) are core-shell nanoparticle structures comprising polymer cores and lipid/lipid-PEG shells, which exhibit complementary characteristics of both polymeric nanoparticles and liposomes, particularly in terms of their physical stability and biocompatibility. Significantly, the LPNs have recently been demonstrated to exhibit superior in vivo cellular delivery efficacy compared to that obtained from polymeric nanoparticles and liposomes. Since their inception, the LPNs have advanced significantly in terms of their preparation strategy and scope of applications. Their preparation strategy has undergone a shift from the conceptually simple two-step method, involving preformed polymeric nanoparticles and lipid vesicles, to the more principally complex, yet easier to perform, one-step method, relying on simultaneous self-assembly of the lipid and polymer, which has resulted in better products and higher production throughput. The scope of LPNs' applications has also been extended beyond single drug delivery for anticancer therapy, to include combinatorial and active targeted drug deliveries, and deliveries of genetic materials, vaccines, and diagnostic imaging agents. This review details the current state of development for the LPNs preparation and applications from which we identify future research works needed to bring the LPNs closer to its clinical realization.
Keywords
Magnetic resonance imaging
CT
MRI
peg
drug delivery
quantum dots
folic acid
dox
liposomes
paclitaxel
plga
doxorubicin
epr
computed tomography
gene delivery
pla
cholesterol
transferrin
tpgs
docetaxel
pc
pet
psma
hybrid nanoparticles
gfp
pei
dimethyl sulfoxide
polyethylene glycol
pbs
dmso
sirna
red blood cells
pva
mrna
combretastatin
lipid polymer
tnf
small interfering rna
tumor necrosis factor
poly(vinyl alcohol)
1,2-dilauroyl-sn-glycero-3-phosphocholine
1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine–polyethylene glycol
1,2-dioleoyl-3-trimethylammonium-propane
1,2-dioleoyl-sn-glycero-3-phosphocholine
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
1,2-dipalmitoyl-3-trimethylammonium-propane
1,2-dipalmitoyl-sn-glycero-3-phosphocholine
1,2-distearoyl-sn-glycero-3-phosphoethanolamine–polyethylene glycol
3β-[n-(n′,n′-dimethylaminoethane)-carbamyl] cholesterol
aunc
bhem-chol
cea
cmt
com
chol
core shell nanoparticles
dc-chol
dcx
dlpc
dmf
dmpe–peg
dopc
dope
dotap
dppc
dptap
dspe–peg
dtpa
fa
fa-oqlcs
fap
hcl
l/p
lpns
mal-peg-dspe
n,n-bis (2-hydroxyethyl)-n-methyl-n-(2-cholesteryloxycarbonyl aminoethyl) ammonium bromide
pbae
pcx
pdi
peg-oqlcs
peg–pe
pfbt
print
particle replication in non-wetting templates
qd
rbc
re
reynolds number
tf
camptothecin
carcinoembryonic antigen
d-α-tocopherol peg 1000 succinate
diethylene-triamine-pentaacetate
dimethyl formamide
enhanced permeability and retention
fibroblast activation protein
folic acid conjugated octadecyl-quaternized lysine modified chitosan
gold nanocrystals
green fluorescent protein
hydrogen chloride
lipid polymer nanoparticles
lipid to polymer
mpeg–dspe
mpeg–pla
maleimide-terminated polyethylene glycol 1,2-distearoyl-sn-glycero-3-phosphoethanolamine
messenger rna
methoxy polyethylene glycol–1,2-distearoyl-sn-glycero-3-phosphoethanolamine
methoxy polyethylene glycol–poly(lactic acid)
o/w
oil-in-water
phosphate buffer saline
phosphatidylcholine
poly [(9,9-dioctylfluorenyl-2,7-diyl)-co-(1,4-benzo-(2,1′,3) thiadiazole)]
poly β-amino ester
poly(ethylene terephthalate)
poly(ethyleneimine)
poly(lactic acid)
poly(lactic-co-glycolic acid)
polydispersity index
polyethylene glycol conjugated octadecyl-quarternized lysine modified chitosan
polyethylene glycol–phosphoethanolamine
prostate specific membrane antigen
scfv
sctnf
single-chain fv fragments
single-chain tumor necrosis factor
w/o/w
water-in-oil-in-water
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Citation
ID:
76279
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NFT Contract Address:
0x95644003c57E6F55A65596E3D9Eac6813e3566dA
Article ID:
76279
Unique Identifier:
10.1016/j.ejpb.2013.07.002
Network:
Scimatic Chain (ID: 481)
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