Individual metakaolin-based alkali activated binder (AAB) was utilized to optimize binary and ternary ones having feldspar/metakaolin and slag/feldspar+metakaolin ratios of 0.3 and 0.4, respectively. These three AABs had the ability to directly solidify 10.0 (FMK0-10R), 8.0 (FMK3-8R) and 12.0% (S4FMK3-12R) of the nuclear grade KY-2 beads, respectively, recording compressive strength values greater than twice the waste acceptance criteria. Leaching of Cs, Co and Eu, whether singularly or multiply loaded, was assessed. The multi-radionuclidic systems recorded greater leached fractions in the order of: Eu>Cs>Co. Among the studied systems, S4FMK3-12R formulations recorded the lowest diffusion coefficient values (D). Gamma-irradiation made a desired influence on all studied leaching systems with inverse relationships with the applied irradiation doses. Irradiating the optimized ternary AAB with 3.0 KGy (S4FMK3-12R-ɣ3) yielded the lowest D value (6.65 × 10 cm/s), when single component-Co was diffused. The leachability indexes of all irradiated AABs were not only greatly exceeded the value of 6 but also sometimes be twice such value. XRD, FT-IR and SEM examinations of S4FMK3, S4FMK3-12R and S4FMK3-12R-ɣ3 reflected their multi-layered semicrystalline natures and to what extent these AABs and the solidified beads had good and poor radiation stabilities, respectively, with a proposed three-step mechanism of such instability.