Ribosomal incorporation of aromatic oligoamides as peptide side-chain appendages.
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Ribosomal incorporation of aromatic oligoamides as peptide side-chain appendages.

Tsiamantas, Christos;Kwon, Sunbum;Rogers, Joseph Matthew;Douat, Céline;Huc, Ivan;Suga, Hiroaki;
angewandte chemie (international ed in english) 2020
221
tsiamantas2020ribosomalangewandte

Abstract

Derivatives of 4-aminomethyl-L-phenylalanine having aromatic oligoamide foldamers as side chain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent ribosomal incorporation both at the C-terminus of, and within, peptide sequences, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome machinery to side-chains significantly larger and more structurally defined than was previously known.

Keywords

aromatic foldamers flexizyme foldamer-peptide hybrids in vitro translation translation elongation

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DOI:
10.1002/anie.201914654

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ID: 76107
Ref Key: tsiamantas2020ribosomalangewandte
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