Drought stress is one of most dramatic abiotic stresses, reduces crop yield significantly. Application of hormones proved as an effective drought stress ameliorating approach. 24-Epibrassinolide (EBL), an active by-product from brassinolide biosynthesis increases drought stress tolerance in plants significantly. EBL application enhances plant growth and development under drought stress by acting as signalling compound in different physiological processes. This article discussed potential role of 24-epibrassinolide application and drought tolerance in plants. Briefly, EBL sustains or improves plant growth and yield by enhancing carbon assimilation rate, maintaining a balance between ROS and antioxidants and also plays important role in solute accumulation and water relations. Furthermore, we also compared different EBL application methods and concluded that seed priming and foliar application are more productive as compared with root application method. In conclusion, EBL is very impressive phyto-hormone, which can ameliorate drought stress induced detrimental effects in plants.