Biomedical wearable sensors enable long-term monitoring applications and provide instantaneous diagnostic capabilities. Physiological monitoring can help in both the diagnosis and the ongoing treatment of a vast number of cardiovascular and pulmonary diseases such as hypertension, dysrhythmia, and asthma. In this paper, we present a system capable of monitoring several vital signals and physiological variables that determine the cardiopulmonary activity status. We explore direct measurements of multiple vital parameters with only one sensor and without special constraints. The system employs a PZT-4 piezo transducer stimulated by a suitable analog front end. The system both generates pulsed ultrasound waves at 1 MHz and amplifies reflected echoes to track internal organ motions, mainly that of the heart apex. According to the respiratory motion of the heart, the proposed system provides respiratory and heart cycles information. Promising results were obtained from six subjects with an average accuracy of 96.7% in heartbeats per minute measurement, referenced to a commercial photoplethysmography sensor. It also exhibits 94.5% sensitivity and 94.0% specificity in respiration detection compared to a spirometer signal as a reference.