Enantioselective organocatalytic Hantzsch synthesis of polyhydroquinolines.
Abstract
The four-component Hantzsch reaction provides access to pharmaceutically important dihydropyridines. To expand the utility of this method, we have developed a route under organocatalytic conditions with good yields and excellent ee's. Through catalyst screening, we found that a BINOL-phosphoric acid allowed enantioselective synthesis of six-membered heterocycles with a variety of substitution patterns.
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DOI:
10.1021/ol901114f
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74077
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Article ID:
74077
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10.1021/ol901114f
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Scimatic Chain (ID: 481)
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