This research aims at finding out the role of interaction in job satisfaction (Z) and its influence on exogenous variables: the organizational culture (X1) and competence (X2) for endogenous variables: employee performance (Y) of the Theological College Evangelical Protestant Church in Banjarmasin. This study is an explanatory research with quantitative approach. Primary data  have  been  collected  using  questionnaires.  Research  respondents  used saturated sample with 31 employees of STT GKE. Data analysis technique to find out the role of interaction on the influence of exogenous variables X1 & X2 on endogenous variables (Y) used Partial Least Square (PLS) analysis technique with Smart PLS 3.0. software. The result of this research concludes that there is an influence of organizational culture (X1) on employee performance (Y) and there is job satisfaction (Z) interaction on the competence of the employee performance (Y). Another finding is that there is no influence of competence variable (X2) on employee performance (Y) and there is no job  satisfaction (Z) interaction on organizational culture (X1) influence towards employee performance (Y).