Much has been written about the need for participants on global health service-learning experiences to contemplate ethical features of their involvement. This literature tends to neglect the role of self-interest in global engagement, however. This article explores how awareness of one's own interests is critical to successfully engaging in global health experiences and proposes how US-based health professions students and trainees can practice critical self-exploration. Six themes beginning with the letter (identity, ideology, ignorance, imagination, intention, and investment) are introduced as guides to nourish conscientious, collaborative global health learning and practice.