Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides
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Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides

Shablykin, Oleh V.;Kornii, Yurii Eu.;Dyakonenko, Victoriya V.;Shablykina, Olga V.;Brovarets, Volodymyr S.;
current chemistry letters 2019 Vol. 8 pp. 199-210
321
shablykin2019synthesiscurrent

Abstract

Obtained by the interaction of 2-amino-3,3-dichloroacrylonitrile and chlorosulphonyl isocyanate (Z)-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride reacts easily with excess of the aliphatic amine to form new (Z)-N-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)-N'-substituted sulfonamides. According to the National Cancer Institute (USA) examinations, two of the six synthesized sulfonamides showed a high anticancer activity.

Keywords

chemistry Microbiology Therapeutics. Pharmacology Biology (General) Medicine Pediatrics Science water supply for domestic and industrial purposes

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