In view of high content of cadmium (Cd) in Chlamys farreri, a commercial edible shellfish species, depurating Cd from Chlamys farreri is an important topic nowadays, especially in short time. Therefore, three kinds of additives were introduced into seawater respectively, i.e. ZnSO, EDTA-Na, sodium citrate, to depurate Cd from Chlamys farreri. The alteration of Cd content in separate organs was investigated under several treatments with high depuration efficiency. The results showed that Cd was depurated exceeding 20% within 12 h by the combination of 0.15 g/L sodium citrate, 0.28 g/L ZnSO, and 0.42 g/L EDTA-Na. No obvious increase of Cd was observed in the adductor muscles, while Cd decreased in the other part, so the reduction of Cd in the whole organism of Chlamys farreri may occur. Cd reduction was found in the following organs: the digestive gland, kidney, gill, and mantle. Furthermore, Cd migration to gonad from other tissues was noticed.