Objective: Renal Replacement therapy for end stage renal disease (ESRD) patients includes transplantation and dialysis. Kidney transplantation is the treatment of choice for ESRD. However, transplant patients are susceptible to infection and cardiovascular disease due to immunosuppressive regimens and existing multiple comorbidities. In this retrospective study, we aimed to investigate the demographic characteristics, clinical manifestations, laboratory findings and outcomes of transplant patients who were admitted to the emergency department.Methods: Transplant patients who were subsequently admitted to the emergency department were retrospectively evaluated. The patients’ demographic, clinical and laboratory findings, symptoms, diagnoses, duration of hospitalization and outcomes were obtained from medical records. Transplant patients with previous hospital protocol numbers of each patient were enrolled into study as control group.Results: 218 patients  were enrolled into study.  More than half of the patients in each group were young women with live kidney donors. The mean (±SD) age of the patients was 39.4±13.2. Chronic glomerulonephritis was the leading etiology of kidney failure among both groups in those where the etiology was identified. The most common symptoms were fever and dysuria. Urinary tract infection was the most frequently diagnosed complication. Mean (±SD) duration of hospitalization was 11.7±9.2 day. Kidney function worsened in 35 patients (16%) and hemodialysis was initiated in 15 of them. Five patients (2.2%) died (sepsis in three, encephalitis in 2).Conclusion: Physicians should have a high index of suspicion for infection during evaluation of organ transplant recipients in the emergency department.