The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses.
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The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses.

Sag, Duygu;Ayyildiz, Zeynep Ozge;Gunalp, Sinem;Wingender, Gerhard;
Cancers 2019 Vol. 11
266
sag2019thecancers

Abstract

Expression of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) by immune cells can lead to the induction of apoptosis in tumor cells. However, it becomes increasingly clear that the interaction of TRAIL and its death receptors (DRs) can also directly impact immune cells and influence immune responses. Here, we review what is known about the role of TRAIL/DRs in immune cells and immune responses in general and in the tumor microenvironment in particular.

Keywords

apoptosis tumor immune regulation lymphoid cells myeloid cells

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