Blind separation of the electroencephalogram signals (EEGs) using topographic independent component analysis (TICA) is an effective tool to group the geometrically nearby source signals. The TICA algorithm further improves the results if the desired signal sources have particular properties which can be exploited in the separation process as constraints. Here, the spatial-frequency information of the seizure signals is used to design a constrained TICA for the separation of epileptic seizure signal sources from the multichannel EEGs. The performance is compared with those from the TICA and other conventional ICA algorithms. The superiority of the new constrained TICA has been validated in terms of signal-to-interference ratio and correlation measurement.