The aim of this manuscript was to show a review about historical data, uses, advantages and disadvantages of spermicidal products. Conducting a search in several biomedical databases and using some terms such as Contraception, Spermatozoa, Spermicides, Nonoxynol-9, Microbicide and Natural Products there was realized a literature review selecting different scientific articles, documents and guidelines that allowed the realization of this work. Contraception has been a worldwide interest subject since a long time ago, implicating aspects such as natality control and sexual transmitted infections. Eventually, due to the increased knowledge in contraception, some spermicidal products have been developed including the synthetic ones. However, different organizations have paid attention to the necessity for seeking new compounds with spermicidal and microbicidal activity, associated to minimal side effects; among these new molecules, the present article highlight those potential spermicides derived from natural products.