People, places, and production contributing the least to climate change will suffer the most. This calls for adaptation as a key climate change response. But adaptation is surrounded by problems. Finance is uncertain and fragmented, mainstreaming into development is complicated, and technical solutions often overshadow existing social relations and institutions. From a gender perspective, and as a critical research initiative to support the building of sustainability science as an umbrella field, this article raises three pertinent questions on adaptation in the global South: what is its purpose, how can development inform it, and what institutions in terms of rights and responsibilities are core to it? Focusing on sub-Saharan small-scale agriculture, three main points emerge. Regarding the purpose, adaptation should be a transformative pathway out of poverty, ill-health, and food insecurity. Regarding development, adaptation can learn from how development theory, policy, and practice have addressed women, gender, and environment in varied settings and debates. Regarding core institutions, adaptation must address gender regimes that regulate access to, use of, and control over resources, especially those defining land distribution, labour division, and strategic decision-making power. To conclude, I propose gender-informed research questions for further inquiry.