DNA-Encoded Macrocyclic Peptide Library.
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DNA-Encoded Macrocyclic Peptide Library.

Zhu, Zhengrong;Shaginian, Alex;Grady, La Shadric C;Davie, Christopher P;Lind, Kenneth;Pal, Sandeep;Thansandote, Praew;Simpson, Graham L;
methods in molecular biology (clifton, nj) 2019 Vol. 2001 pp. 273-284
162
zhu2019dnaencodedmethods

Abstract

DNA-encoded library technology (ELT) is a cutting-edge enabling technology platform for drug discovery. Here we describe how to design and synthesize a macrocyclic DNA-encoded library; how to perform selection, sequencing, and data analysis to identify potential active peptides; and how to synthesize off-DNA peptides to confirm activity. This approach provides an effective tool for pharmaceutical research based on peptides.

Keywords

affinity selection dna-encoded library macrocyclic peptides

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DOI:
10.1007/978-1-4939-9504-2_12

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ID: 53699
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53699
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10.1007/978-1-4939-9504-2_12
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