Blast furnace dust (BFD), a hazardous metallurgical waste, is generated during the iron-making process and consists plenty of Fe and C. This study is among the first to apply BFD in catalytic-ceramic-filler (CCF) preparation and degradation of ciprofloxacin (CIP). The novel BFD based Fe-Ni CCF obviously enhanced the removal of CIP (from around 42%-72% after 3 h) in comparation with troditional Fe-C ceramic-filler(CF). The Fe-Ni CCF was further applied in a coupled system of electrolysis assisted catalytic micro-electrolysis (E-CME) process for CIP wastewater treatment. Under optimal operating conditions (iron rod as anode, voltage of 10v and HRT of 3 h), nearly 97% of CIP, 90% of total organic carbon (TOC) and 99% of total phosphorus (TP) were removed by E-CME process in near-neutral solution. The degradation mechanism analysis by LC-MS revealed that polyhydroxy sub-stituted, piperazine rings cleavage and so on were the main reaction of CIP in E-CME process. Additionally, the chemical oxygen demand (COD) residue after E-CME process could be effectively eliminated by up-flow anaerobic filter (UAF), owing to the significant improvement of wastewater biodegradability by E-CME pretreatment. This study provides a new way for co-friend recycling of BFD and a highly-efficient, cost-sffective technology for CIP wastewater treatment.