Sodium-sulfur batteries using abundant elements offer an attractive alternative to currently used batteries, but they need better sulfur host materials to compete with lithium-ion batteries in capacity and cyclability. We report an sulfur-doping strategy to functionalize MXene nanosheets by introducing heteroatomic sulfur into the MXene structure form the MAX phase precursor. By employing the vacuum freeze-drying method, a three-dimensional (3D) wrinkled MXene nanoarchitecture with the high specific surface area was prepared. The tailor-made wrinkled sulfur-doped MXene (S-TiCT) nanosheets were applied as an electrode host material in room temperature sodium-sulfur batteries. The S-TiCT matrix shows high polarity with sodium polysulfides, restricting the diffusion of sodium polysulfides. The MXene/sulfur electrode can achieve high areal sulfur loading up to 4.5 mg cm as well as good electrochemical performance (reversible capacity of 577 mAh g at 2 C after 500 cycles).