This paper analyses the relationship between inequality and de facto regional economic integration during the last two decades in Latin America and East Asia Pacific regions, focusing on intra-regional exports. Globalization has been considered as a driving of inequality, although export-led growth models are associated with high economic growth rates. Export-led growth models have been more dynamic in East Asia than in Latin America, through the development of supply chain networks of intermediate and final goods. Research questions explore the relation between inequality and patterns of de facto intra-regional trade. Empirical analysis uses a fixed effects panel data with Heteroskedasticity and Autocorrelation Consistent (HAC) covariance matrix. Results showed that increments in regional intra-trade are associated with reductions of inequality, more in East Asia Pacific than in Latin America. The contribution of this paper is the introduction of intra-regional trade as a new factor that is negatively associated with inequality.