This study is aimed to determine the main effects of CBT group, social support group (DS) and control group (KK) on the self esteem among breast cancer patients. Rosemberg self esteem scale (RSE) was used to measure self-esteem. The treatment group consisted of CBT and DS groups. Each treatment group received 12 counselling sessions within six weeks. Quantitative analysis general linear model (GLM) repeated measures was used to identify the groups'; (CBT, DS, and KK) main effect, the repeated test RSE scale (pre test, post test 1, post test 2, and post test 3) main effect and the interaction effect (CBT, DS, and KK), and repeated tests RSE scale (pre test, post test 1, post test 2, post test 3). There was no significant difference in the groups (CBT, DS, and KK) main effect on the Rosenberg Self Esteem (RSE) scores. There was a significant difference (F (3.10) = 66.823, p = 0.0001 (Wilk's Lambda) on the repeated test RSE scale (pre test, post test 1, post test 2, and post test 3) main effects on self esteem score. Overall findings showed an increase in RSE scores between the pre test, post test 1, post test 2 and post test 3.