Patients in the hospital should be treated promptly. It will improve the quality of services and patient safety. The objective of this paper is to investigate factors affecting patient assessment response in nursing practice based on a review of the literature.A systematic review was utilized. The article was conducted using online databases, reference lists of key articles, and expert advice. Multiple keyword combinations were used. All relevant studies were subsequently appraised for rigorous and quality.Eleven articles were critically appraised. The results show that there are six factors that affect patient assessment responses: (1) high specific competences; (2) clinical experiences; (3) patient safety culture; (4) education level; (5) team collaboration; and (6) medical systems. High specific competence of nurse is significant affected the patient assessment response.Factors that enhancing nurse's assessment response should be special attention in health care services. Nurses manager have a substantial role in enhancing response assessment of nurses' practitioner.