Objective:To assess the prevalence and risk factors associated with mild cognitive impairment (MCI) in Thai menopausal women.Materials and Methods: The eligible menopausal women were asked during a face-to-face interview to participate in the Thai Montreal Cognitive Assessment (Thai MoCA) test at HRH Princess Maha Chakri Sirindhorn Medical Center. Cognitive impairment was defined as a test’s score of 24 or less. Univariate and multivariate analyses were performed to determine the variable associated with positive Thai MoCA test. Results:The authors found that 20 of the 120 participants were cognitively impaired. The significant associated risk factors were low education (adjusted odd ratio: 3.7; p= 0.03) and the number of concomitant medical diseases. The adjusted odd ratios for one, two and three diseases were 18.0, 42.1 and 88.9 respectively.Conclusion: The prevalence of MCI in menopausal women was 16.7 %. Early detection of this problem in vulnerable group will benefit to their cognitive performance.