The present research has introduced a novel adaptive state-dependent impulsive observer (ASDIO) used to control diverse nonlinear systems with time-varying delay. This designed ASDIO is in conformity with the approach of extended pseudo-linearization for the purpose of parametrizing a nonlinear system with time-delay to a pseudo-linear time-delay structure having state-dependent coefficients. This technique makes the ASDIO applicable to nonlinear systems with distributed, multiple, and time-varying delays. The time-varying and delay-independent Lyapunov functional approach, coupled with the comparison method for impulsive systems, was used to confirm the stability of ASDIO. This new theorem affirmed the state and parameter estimation error to approach zero asymptotically through distinct and less-conservative adequate conditions with respect to practical linear matrix inequalities. Furthermore, the maximum impulse time was specified via the presented stability theorem. The ASDIO has also been offered for a special set of stochastic nonlinear systems with time-delay. An investigation of the asymptotic stability for the intended ASDIO was performed via a new theorem employing the comparison principle for stochastic impulsive systems. Accordingly, this observer was simulated on an epidemic system with time-delay nonlinear features to affirm its performance.