In vitro antiprotozoal activity of some medicinal plants against sleeping sickness, Chagas disease and leishmaniasis.
Abstract
Antiprotozoal activity of 36 medicinal plants was evaluated.In vitro potency against Trypanosoma brucei brucei, T. b. rhodesiense, T. cruzi and Leishmania infantum beside cytotoxicity on MRC-5 fibroblasts were determined.Maytenus parviflora showed the highest activity against T. b. brucei (IC of 0.6 μg/ml) and T. b. rhodesiense (IC of 0.5 μg/ml) with low cytotoxicity (CC of 30 μg/ml). Saussurea costus and Commiphora wightii, showed pronounced potency against T. cruzi with an IC of 3.6 and 2.5 μg/ml, respectively. Jatropha pelargonifolia and Solanum villosum exhibited pronounced activity toward L. infantum with an IC of 3.2 and 2.0 μg/ml, respectively. M. parviflora, S. costus, C. wightii, J. pelargonifolia and S. villosum showed relevant selectivity.
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40281
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0x95644003c57E6F55A65596E3D9Eac6813e3566dA
Article ID:
40281
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10.4155/fmc-2018-0180
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Scimatic Chain (ID: 481)
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