Aim: This was an ethnobotanical study that was carried out to establish the traditional uses of Lantana trifolia L. and Sida cuneifolia Roxb. plants in selected parts of Central Uganda. Methods: The ethnobotanical study was done in August and September, 2012 in Mukungwe and Wabinyonyi sub-counties in Masaka and Nakasongola Districts respectively located in Central Uganda. Study sites and respondents were purposefully selected and information was obtained through semi-structured interview guides, key informant interview guides as well as observations. Eighty respondents were considered for semi-structured interviews and 15 for key informant interviews. Results: Seven ethnobotanical uses for Lantana trifolia were cited by respondents and majority (46.25%) of them used it as a herbal remedy. As a herbal remedy, Lantana trifolia managed 13 human disease conditions and mainly used in the management of cough and common colds by 22.5% of the respondents. Four ethnobotanical uses were cited for Sida cuneifolia and majority of the respondents (62.5%) used it as a herbal remedy as well as sweeping brooms. As a herbal remedy, Sida cuneifolia was reported to be useful in management of 12 disease conditions, fractures and sprains (bone setting) being mentioned by the majority of the of respondents (36.25 %). Conclusion: In conclusion, Lantana trifolia and Sida cuneifolia were culturally important ethnomedicines. Scientific validation of traditional claims as well as conservation of these plants should be encouraged in order to preserve and promote their use. [J Intercult Ethnopharmacol 2013; 2(3.000): 155-164]