The Coping With Discrimination Scale (CDS) shows promise as a self-report measure of strategies for coping with racial discrimination. To assess the psychometric properties of the measure for use with sexual minorities (i.e., gay, lesbian, bisexual, or GLB persons), a nonprobability sample of 371 GLB adults completed the instrument along with several standardized, self-report measures. Confirmatory factor analyses supported the five-factor structure of the original scale with the exclusion of five items. Adequate internal consistency reliability was found. Internalization, drug and alcohol use, and detachment subscales were correlated positively with measures of psychological distress and negatively with a measure of life satisfaction, providing evidence of construct validity. The education/advocacy and resistance subscales were largely unrelated to concurrently administered validation measures, consistent with prior findings. Coping strategy use varied as a function of primary sources of social support. The CDS appears to be a psychometrically sound measure of several discrimination coping strategies for use with sexual minorities.