Analyzed organization of preventive measures and  patient  care  in  Velikiy Novgorod in  connection with  the  exceeding of the  epidemic threshold for influenza and  acute respiratory viral  infections in  2016.  The  epidemic rise  of influenza and  other  acute  respiratory viral  infections exceeded epidemiological and economic thresholds among  the cumulative population on the  territory  of the  Novgorod region started from the 3rd week 2016 (18.01.2016–24.01.2016) and continued for 4 weeks (until  mid February).  The peak  of the epidemic was passed on the 4th calendar week  of 2016, when  the weekly prevalence rate was 135,7 per 10 thousand population (8447),  the  epidemic  threshold was  exceeded in 2 times. In terms  of conversion to the  infectious diseases hospital, a multidisciplinary clinic № 2 «Central city clinical hospital» carried  out specialized medical assistance 301 the patient with  acute respiratory diseases and  influenza, 67 of which were confirmed influenza caused by the H1N1 virus, of which  28 patients would,  if hospitalized in serious  and critical condition and  needed to be held-Institute the  intensive care manual.