Accurate alignment is a basic principle of TKA surgery, but achieving alignment within this target may not translate into superior outcomes after surgery.To assess if neutral TKA mechanical alignment was associated with superior knee outcomes and to examine the effect of various aspects of pre-operative and post-operative alignment on knee function.Analysis of a database of 444 TKA patients between June 2009 and October 2016. Knee outcomes (WOMAC, AKSS and knee range of motion) were collected before surgery and during follow-up at a minimum of six months.Analysis included 444 TKA patients (62% female, mean age 66 years, mean follow-up 23 months). Deformity varied from 21° varus (mean = 7.9, SD = 2.8) to 17° valgus deformity (mean = 7.7, SD = 2.8). Pre-operatively, 101 (23%) knees were in native neutral mechanical alignment, while 278 (63%) were in varus and 65 (15%) were in valgus. Post-operatively, a group of 365 (82%) TKA were found to be in neutral mechanical alignment and a group of 79 (18%) TKA were noted to be 'Outliers' (17 [4%] TKA > 3° varus and 62 [14%] TKA > 3° valgus alignment). Restoration of the target of alignment of 0 ± 3° or 0 ± 1°, did not have better functional outcomes scores, range of motion or prosthesis longevity than those in the outlier range.Neutral TKA alignment did not appear to be a significant contributing factor to the improvement in knee function in short-medium term follow-up.