Educational attainment is one of the strongest determinants of subjective health and well-being. Minorities' Diminished Returns, however, suggests that such an effect may be smaller for the members of racial/ethnic minorities such as Blacks and Hispanics relative to non-Hispanic Whites. Only one study has previously shown that minorities' diminished returns may also apply to lesbian, gay, and bisexual (LGB) individuals; however, that study has focused on other outcomes (i.e., obesity). To compare LGB and non-LGB American adults for the effects of educational attainment on subjective health and well-being. This cross-sectional study used baseline data of 31,480 adults in the Population Assessment of Tobacco and Health (PATH, 2013), a nationally representative study in the United States. The independent variable was educational attainment. The dependent variable was subjective health and well-being, measured using four items. Race, ethnicity, age, gender, poverty status, and employment were the covariates. LGB status was the moderator. Overall, individuals with higher educational attainment had better subjective health and well-being. We found a significant interaction between LGB status and educational attainment which was suggestive of that the boosting effect of high educational attainment on better subjective health and well-being was systemically smaller for LGB than non-LGB individuals. In the United States, highly educated LGB adults experience poor subjective health and well-being, a status that is disproportionate to their educational attainment.