Immunological diseases of the skin are serious concern to dermatologist all over the world. Treatment of such diseases is big challenge and topical immune modulators have been proved to be effective in this. Various anti-inflammatory drugs have been used for this purpose since long with multiple adverse effects. 100 Pt. different dermatoses included in this study are atopic dermatitis, alopecia areata, pyoderma gangrenosum, psoriasis, contact dermatitis, cutaneous lupus erythematous, chronic actinic dermatitis, vitiligo, lichen sclerosis dyshydrotic palmar eczema. Tacrolimus was found to be effective in the treatment of immunological skin disorder.