The purpose of this study was to investigate the clinical impact on the global function of the shoulder of the use of the anterolateral approach for nailing.A retrospective cohort at the public sector of Centenario Hospital Miguel Hidalgo in Aguascalientes, Mexico between 2011 and 2016 was analysed. Inclusion criteria were: patients with anterolateral humeral nailing approach. Clinical assessment using the Constant-Murley score, shoulder range of motion and quick DASH questionnaire.Seventeen patients, 16 treated for humeral shaft fracture and one for humeral fibrous dyslasia were obtained. Mean score on Constant-Murley scale was 84.05 with 76.4% of patients achieving excellent result ( 75 points). One patient had a poor functional outcome. The mean quickDASH score was 17.5 points.The anterolateral approach for humeral nailing has good functional outcome in our series.