Systematic tuning of heme redox potentials and its effects on O2 reduction rates in a designed oxidase in myoglobin
Abstract
Cytochrome c Oxidase (CcO) is known to catalyze the reduction of O2 to H2O efficiently with a much lower overpotential than most other O2 reduction catalysts. However, methods by which the enzyme fine-tunes the reduction potential (E°) of its active site and the corresponding influence on the O2 red …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Molecular
animals
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
male
N.I.H.
Extramural
oxidation-reduction
binding sites
heme / chemistry*
hydrogen bonding
Oxygen / chemistry*
electron transport complex iv / metabolism
biocatalysis
serine / genetics
protein engineering
spermatozoa / metabolism
heme / metabolism
myoglobin / chemistry*
myoglobin / metabolism
whales
alanine / genetics
pmid:25076049
pmc4151708
doi:10.1021/ja5054863
ambika bhagi-damodaran
igor d petrik
yi lu
copper / chemistry
electron transport complex iv / chemistry*
electron transport complex iv / genetics
heme / genetics
histidine / genetics
myoglobin / genetics
Citation
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283955
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