Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-kappa B
Abstract
Reactive oxygen species (ROS) generated by the cellular NADPH-oxidase are crucial for phagocytic killing of ingested microbes and have been implicated as signaling molecules in various processes. For example, ROS are thought to be involved in activation of the transcription factor NF-kappaB, central …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
male
Cells
Cultured
reactive oxygen species / metabolism*
cytokines / biosynthesis
nf-kappa b / metabolism*
chronic / pathology*
membrane glycoproteins / genetics
granulomatous disease
leukocytes / immunology*
chronic / immunology*
nadph oxidases / genetics
nadph oxidase 2
membrane glycoproteins / deficiency
nadph oxidases / deficiency
pmid:17330823
doi:10.1002/eji.200636651
johan bylund
kelly l macdonald
david p speert
chronic / metabolism
leukocytes / metabolism
leukocytes / pathology*
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283823
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