Amputation resulting from diabetes remains a significant public health challenge in Ghana, often culminating in morbidity and mortality. Nurses are the frontline health workers that often manage these patients. This qualitative study explores nurses' experiences and challenges in the care and management of patients undergone amputation due to diabetic complications at the Sunyani Teaching Hospital in Ghana. Using a phenomenological approach, semistructured interviews were conducted with nurses working in diabetic and surgical units across the Sunyani Teaching Hospital (STH) between April 2024 and July 2024. This study showed that nurses face emotional burdens, resource constraints, patient‒nurse relationships, and coping mechanisms in the bid to care for patient with diabetic related amputation. The findings provide invaluable insights into the challenges faced by nurses and suggest strategies for improving care delivery and outcomes for individuals with diabetic amputation. Not applicable.