The relationship between social support, coping strategies, spirituality, and psychological well-being in breast cancer survivors is crucial in psycho-oncology. Survivors face complex challenges, and the interplay of these factors affects their recovery. Social support, encompassing emotional, informational, and practical assistance, is pivotal, offering belonging and resilience. Coping strategies, whether adaptive (like problemsolving) or maladaptive (like denial), significantly impact psychological outcomes. Spirituality, irrespective of ties to organized religion, significantly impacts the psychological well-being of breast cancer survivors. It provides a framework for understanding and coping, offering hope and meaning. Psychological status encompasses emotional well-being, mental health, and quality of life, influenced by cancer severity, personality traits, social support, coping strategies, and fear of recurrence. Methodology for literature review: The literature review employed a systematic approach, utilizing various databases and search terms to identify recent research on the relationship between social support, coping strategies, spirituality, and psychological status among breast cancer survivors. Inclusion criteria focused on relevance and rigor, with a thematic emphasis on the interplay between these factors. Both qualitative and quantitative studies from peer-reviewed journals were considered within a specific time frame (2010-2023) to capture recent advancements. The screening process involved two independent reviewers, with disagreements resolved through discussion. Data extraction and synthesis involved carefully analyzing study characteristics, key findings, and implications for survivorship. The analysis aimed to provide a comprehensive overview and identify future research directions. Understanding the dynamics of social support, coping strategies, spirituality and psychological status among breast cancer survivors is essential for developing effective interventions and support systems. By addressing and challenging societal attitudes, promoting awareness and education, and fostering supportive environments, Healthcare professionals can help breast cancer survivors overcome they face, enhance their coping mechanisms, bolster their social support networks, and ultimately improve their psychological status.