Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterised by a complex aetiology that encompasses genetic, environmental, and immunological factors. A comprehensive understanding of SLE aetiology is essential for the development of effective therapeutic strategies and the enhancement of patient outcomes. This study aims to provide a thorough bibliometric analysis of research concerning the aetiology of SLE conducted over the past decade. A bibliometric analysis was conducted based on articles published between January 2014 and December 2023, retrieved from the Web of Science Core Collection database. The analysis employed the R package 'bibliometrix', as well as VOSviewer and CiteSpace. A total of 5,825 publications were analysed. The results underscore the global collaborative nature of SLE research, with significant contributions from China, the USA, and Japan. Notable institutions included Harvard University, the Chinese Academy of Medical Sciences, and the Egyptian Knowledge Bank. Influential journals in the field comprised Arthritis & Rheumatology, Annals of the Rheumatic Diseases, and Frontiers in Immunology. Key word analysis revealed a recent emphasis on terms such as 'management','efficacy', and 'safety', together with emerging interests in 'health' and 'genes'. This study provides a bibliometric analysis of SLE aetiology research, highlighting evolving research trends, influential studies, and collaborative networks. The findings indicate a shift in research focus from specific disease pathogenesis and expression toward genetic mechanisms, diagnostic approaches, and clinical applications. Future research on SLE aetiology is likely to prioritise investigations into DNA, genes, and validating existing findings.