Abstract
This study examines the phytochemical characteristics of Ayurvedic products.
An analysis was performed on Kottakkal Ayurveda Triphala (T), Kottakkal
Ayurveda Hinguvachadi Churnam (H), and Kottakkal Ayurveda Jirakadyarishtam (J)
using GC-MS and LC-MS techniques to determine their bioactive constituents,
while also assessing their antimicrobial, docking, anticancer, and
anti-diabetic activities. The GC-MS analysis identified 30, 45, and 8 chemical
components in Kottakkal Ayurveda Triphala (T), Kottakkal Ayurveda Hinguvachadi
Churnam (H), and Kottakkal Ayurveda Jirakadyarishtam (J), respectively. The
LC-MS analysis produced 15, 20, and 16 peaks for Kottakkal Ayurveda Triphala
(T), Kottakkal Ayurveda Hinguvachadi Churnam (H), and Kottakkal Ayurveda
Jirakadyarishtam (J), with m/z values of 982, 981, 972, and 933; 987, 985, 974,
and 945; and 969, 965, 951, and 941, respectively, confirming their precision.
Moreover, characterization of the Ayurvedic products was carried out using
FT-IR, UV-vis, and 1H-NMR spectroscopy to identify significant functional
groups and chemical substances. Kottakkal Ayurveda Triphala (T) was evaluated
for antibacterial activity against Gram-positive bacteria (Streptococcus
pneumoniae and Staphylococcus aureus) along with Gram-negative bacteria
(Escherichia coli and Klebsiella pneumoniae), yielding a P value of 0.0650 (P <
0.0001). Both Kottakkal Ayurveda Hinguvachadi Churnam (H) and Kottakkal
Ayurveda Jirakadyarishtam (J) were subjected to analysis for their
effectiveness against Aspergillus niger and Aspergillus fumigatus, also
revealing a P value within the acceptable range of 0.0650 (P < 0.0001). The
anti-diabetic properties of Kottakkal Ayurveda Triphala (T) were assessed using
the {\alpha}-glucosidase inhibitory method, which exhibited a significant
inhibitory effect on {\alpha}-glucosidase, resulting in an average P value of
0.001 (P < 0.0001).
Citation
ID:
281512
Ref Key:
shareef2024investigation