This study delved into the complex relationship between self-efficacy, coping skills, and personality traits among Tourism college students, all of whom experienced the disruptive effects of the COVID-19 pandemic. Through the administration of three key questionnaires—the New General Self-Efficacy Scale, the Brief COPE Inventory, and the Big Five Inventory—the participants' self-perceptions and coping mechanisms were assessed. The findings revealed that individual personality traits played a significant role in determining the effectiveness of coping strategies employed by students. A strong correlation was identified among self-efficacy, coping skills, and various personality dimensions. These results suggest that institutions facing similar challenges could benefit from tailoring their support systems and educational approaches to align with the unique needs and characteristics of their students, as highlighted by this study. By implementing strategies informed by these insights, educational institutions can better equip students with the tools and support necessary to thrive in challenging circumstances, ultimately fostering a more conducive learning environment.