Large language model (LLM)-powered chatbots have become increasingly prevalent in healthcare, while their capacity in oncology remains largely unknown. To evaluate the performance of LLM-powered chatbots compared to oncology physicians in addressing to colorectal cancer queries.This study was conducted between August 13, 2023, and January 5, 2024. A total of 150 questions were designed, and each question was submitted three times to eight chatbots: ChatGPT-3.5, ChatGPT-4, ChatGPT-4 Turbo, Doctor GPT, Llama-2-70B, Mixtral-8x7B, Bard, and Claude 2.1. No feedback was provided to these chatbots. The questions were also answered by nine oncology physicians, including three residents, three fellows, and three attendings. Each answer was scored based on its consistency with guidelines, with a score of 1 for consistent answers and 0 for inconsistent answers. The total score for each question was based on the number of corrected answers, ranging from 0 to 3. The accuracy and scores of the chatbots were compared to those of the physicians.Claude 2.1 demonstrated the highest accuracy, with an average accuracy of 82.67%, followed by Doctor GPT at 80.45%, ChatGPT-4 Turbo at 78.44%, ChatGPT-4 at 78%, Mixtral-8x7B at 73.33%, Bard at 70%, ChatGPT-3.5 at 64.89%, and Llama-2-70B at 61.78%. Claude 2.1 outperformed residents, fellows, and attendings. Doctor GPT outperformed residents and fellows. Additionally, Mixtral-8x7B outperformed residents. In terms of scores, Claude 2.1 outperformed residents and fellows. Doctor GPT, ChatGPT-4 Turbo and ChatGPT-4 outperformed residents.This study shows that LLM-powered chatbots can provide more accurate medical information compared to oncology physicians.