Objective:The study aimed on determining the comfort level of cancer patients with receiving chemotheraphy and to evaluate the factors that have an impact on this.Methods:The study was conducted with 213 patients who received cancer chemotherapy. It was designed as a cross-sectional and descriptive model. A Patient Information Form and General Comfort Questionnaire was administered to patients in person. For the data assessment, frequency, percentages, the t test, one-way variance analysis, the Mann-Whitney U test, Kruskal -Wallis H test, and the Dunnet T3 Post Hoc test were employed.Results:The average General Comfort Questionnaire score for patients was 2.93±0.35. Patients psychospiritual comfort was at the highest degree (39.72±5.87), while environmental comfort was at the lowest degree (35.58±6.45). Patients comfort level was significantly affected by sex, age and profession (p<0.05), whereas it was not affected significantly by marital status, educational status, person(s) with whom they lived cancer type, duration of cancer (p>0.05).Conclusion:Patients in the study had moderate comfort levels. There is increased recognition that cancer patients comfort needs should be explored, and practices that will enhance their comfort level should be promoted.