Learning is a process of developing new knowledge, skills, and behaviors in a person as a result of his interaction with various information and the environment. The current COVID-19 pandemic has affected the entire education system in Indonesia, from elementary to tertiary levels. This situation requires us to self-isolate at home to stop the spread of the virus. Google classroom can be said as one of the learning media based on the inquiry learning method because google classroom can involve the ability of students to the maximum in finding, understanding, investigating, analyzing and formulating learning outcomes.This study aims to produce online learning media based on google classroom on biology subjects, tissue material in plants, which then the information is packaged in the form of a guidebook for using google classroom in biology subjects. In addition, this study also aims to see the differences in the learning outcomes of students in class XI of the Science Department at Karitas Catholic High School Tomohon.This study uses a development research method by adapting the ADDIE model (Analysis, design, development, implementation, Evaluation). The field trial design used a pre-test post-test control group design technique consisting of students in class XI IPA 1 and Class XI IPA 2 at Karitas Catholic High School Tomohon.