Antakya, known as Antioch during the ancient period, is significant among Turkey’s historical urban contexts. It is located in the south-east of Turkey, near the Syrian border and is the capital of Hatay province. Called the ‘Queen of the East’ at one time, it is an important city historically since it was an early center of Christianity and one of the capital cities of the Roman Empire. As a result of its importance, the city has been formed/re-formed over time by different empires, and many structures from various periods are still persist in the current urban form. The aim of this paper is to examine the French Mandate and Turkish Republican Period urban conservation and development strategies in Antakya in order to better understand their influences and effects on its historical urban core. The paper thus begins with an introduction and brief outline of the historical development of the core of Antakya. The second part focuses on the French Mandate and Turkish Republican Period urban conservation and development plan strategies. The final part discusses the effects of different urban development strategies on the historic core of the city.