Siderophore piracy enhances environmental survival and pathogenesis.
Abstract
the aetiological agent of cholera, possesses multiple iron acquisition systems, including those for the transport of siderophores. How these systems benefit in low-iron, polymicrobial communities in environmental settings or during infection remains poorly understood. Here, we demonstrate that in iron-limiting conditions, co-culture of with a number of individual siderophore-producing microbes significantly promoted growth . We further show that in the host environment with low iron, colonizes better in adult mice in the presence of the siderophore-producing commensal . Taken together, our results suggest that in aquatic reservoirs or during infection, may overcome environmental and host iron restriction by hijacking siderophores from other microbes.
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DOI:
10.1099/mic.0.000975
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ID:
275130
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0x95644003c57E6F55A65596E3D9Eac6813e3566dA
Article ID:
275130
Unique Identifier:
10.1099/mic.0.000975
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Scimatic Chain (ID: 481)
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