Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
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Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

Jacqueline J.L. Jacobs, Blanca Scheijen, Jan-Willem Voncken, Karin Kieboom, Anton Berns, Maarten van Lohuizen;Jacqueline J.L. Jacobs;Blanca Scheijen;Jan-Willem Voncken;Karin Kieboom;Anton Berns;Maarten van Lohuizen;
genes & development 1999 Vol. 13 pp. 2678-
121
lohuizen1999genesbmi-1

Abstract

The bmi-1 and myc oncogenes collaborate strongly in murine lymphomagenesis, but the basis for this collaboration was not understood. We recently identified the ink4a–ARF tumor suppressor locus as a critical downstream target of the Polycomb-group ...

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DOI:
10.1101/gad.13.20.2678
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC317101...

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