Early prenatal androgenization results in diminished ovarian reserve in adult female rhesus monkeys
Abstract
Based on these animals, early PA appears to program an exaggerated decline in ovarian reserve with age, suggesting that epigenetically induced hormonal factors during fetal development may influence the cohort size of ovarian follicles after birth.
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
pregnancy
research support
non-u.s. gov't
female
N.I.H.
Extramural
d a dumesic
d h abbott
macaca mulatta
prenatal exposure delayed effects*
gestational age
recombinant proteins / pharmacology
ovary / drug effects
aging / blood
fertilization in vitro
virilism / blood
testosterone propionate / pharmacology
pmid:19740899
pmc2777787
doi:10.1093/humrep/dep324
m s patankar
anti-mullerian hormone / blood*
embryo culture techniques
follicle stimulating hormone
human / pharmacology
oocyte retrieval / statistics & numerical data
ovary / physiology*
ovulation induction
virilism / chemically induced
virilism / physiopathology*
Citation
ID:
274679
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