Conditional lethality of the diprotic weak bases chloroquine and quinacrine against Cryptococcus neoformans
Abstract
Chloroquine at 10 microM enhances the activity of macrophages against Cryptococcus neoformans but does not directly inhibit cryptococcal growth. The antifungal activity of higher chloroquine concentrations likely to be found within the acidic cryptococcal phagosome was tested. Concentrations of > …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
microbial sensitivity tests
drug combinations
enzyme inhibitors / pharmacology
anti-bacterial agents / pharmacology
cell division / drug effects
antifungal agents / pharmacology*
chloroquine / pharmacology*
t s harrison
s m levitz
macrolides*
pmid:10882608
doi:10.1086/315649
g e griffin
cryptococcus neoformans / drug effects*
cryptococcus neoformans / metabolism
quinacrine / pharmacology*
Access
Citation
ID:
274655
References
Blockchain Verification
Account:
NFT Contract Address:
0x95644003c57E6F55A65596E3D9Eac6813e3566dA
Article ID:
274655
Unique Identifier:
Network:
Scimatic Chain (ID: 481)
Loading...
Blockchain Readiness Checklist
Authors
Abstract
Journal Name
Year
Title
Creates 1,000,000 NFT tokens for this article
Token Features:
- ERC-1155 Standard NFT
- 1 Million Supply per Article
- Transferable via MetaMask
- Permanent Blockchain Record
Scan with Saymatik Web3.0 Wallet