Ectopic expression of the nude gene induces hyperproliferation and defects in differentiation: implications for the self-renewal of cutaneous epithelia
Abstract
Nude mice are characterized by the absence of visible hair, epidermal defects, and the failure to develop a thymus. This phenotype results from loss-of-function mutations in Whn (Hfh11), a winged-helix transcription factor. In murine epidermis and hair follicles, endogenous whn expression is induced …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
phenotype
DNA-Binding Proteins / genetics*
time factors
transcription factors / genetics*
cell differentiation
dose-response relationship
drug
transgenic
epithelium / metabolism
cell culture techniques
cell division
skin transplantation
DNA-Binding Proteins / immunology
forkhead transcription factors
calcium / pharmacology
transcription factors / immunology
pmid:10419685
doi:10.1006/dbio.1999.9328
d m prowse
d lee
j l brissette
eye abnormalities / genetics
keratinocytes
nude / genetics*
protein precursors / genetics
skin / metabolism*
skin abnormalities / genetics
transforming growth factor alpha / metabolism
urogenital system / anatomy & histology
vibrissae / metabolism
vibrissae / ultrastructure
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274600
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