FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells
Abstract
TMPRSS2-ERG and other gene fusions involving ETS factors and genes with strong promoter elements are common in prostate cancer. Although ERG activation has been linked to invasive properties of prostate cancers, the precise mechanisms and pathways of ERG-mediated oncogenesis remain poorly understood …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
gene expression regulation
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
cell line
Receptors
signal transduction / genetics
transfection
neoplastic
up-regulation
gene silencing
epithelial cells / pathology
wnt proteins / metabolism*
prostatic neoplasms / metabolism
prostatic neoplasms / pathology
gene knockdown techniques
prostatic neoplasms / genetics
frizzled receptors / metabolism
trans-activators / biosynthesis
g-protein-coupled / genetics*
pmid:20713528
doi:10.1158/0008-5472.can-10-0244
santosh gupta
kristiina iljin
olli kallioniemi
cadherins / biosynthesis
cadherins / genetics
cell adhesion / genetics
frizzled receptors / genetics*
integrin beta1 / biosynthesis
integrin beta1 / genetics
mesoderm / pathology
g-protein-coupled / metabolism
trans-activators / genetics*
transcriptional regulator erg
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274572
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