Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

Takehiko Kamijo, Jason D. Weber, Gerard Zambetti, Frederique Zindy, Martine F. Roussel, Charles J. Sherr;Takehiko Kamijo;Jason D. Weber;Gerard Zambetti;Frederique Zindy;Martine F. Roussel;Charles J. Sherr;
Proceedings of the National Academy of Sciences of the United States of America 1998 Vol. 95 pp. 8292-
115
sherr1998proceedingsfunctional

Abstract

The INK4a-ARF locus encodes two proteins, p16[INK4a] and p19[ARF] , that restrain cell growth by affecting the functions of the retinoblastoma protein and p53, respectively. Disruption of this locus by deletions or point mutations is a common event in ...

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DOI:
10.1073/pnas.95.14.8292
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC20969/

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